A study on the efficacy of triamcinolone acetonide combined with hyaluronidase injection and superficial X-ray in the treatment of multiple keloids
Wu Lizhen1, Hou Chenrong1, Xie Zhenmou2, Wang Weijia3, Wang Chunmei1
1Department of Plastic & Cosmetic Surgery, Southern Medical University Dermatology Hospital, Guangzhou 510091, China; 2Department of Clinical Laboratory, Southern Medical University Dermatology Hospital, Guangzhou 510091, China;3Department of Radiology, Southern Medical University Dermatology Hospital, Guangzhou 510091, China
Corresponding author: Wang Chunmei, Email:email@example.com
Objective To investigate the clinical application value of triamcinolone acetonide combined with hyaluronidase injection and shallow X-ray in the treatment of multiple keloids.
Methods From March 2018 to October 2019, 144 cases of multiple keloids in outpatient department were analyzed retrospectively. There were 89 males and 55 females, aged from 16 to 68, with an average age of 28 years. The average duration was 6 years(ranged from 1 to 20 years). Among them, 65 cases were treated with superficial X-ray radiotherapy combined with local injection (group A) and 79 cases were treated only with local injection (group B). The Vancouver Scar Scale (VSS), t\|test and chi-square test were used to evaluate the validity of the two groups.
The patients were followed up for 6-18 months.
ResultsIn group A, the VSS was changed from 11.9±0.9 to 6.5±1.1. 51 cases were improved and 14 cases showed obviously effective. The significant effect rate was 21.54%（14/65）. The main side effect of group A was transient pigmentation. In group B, the VSS was changed varied from 12.1±1.0 to 8.3±1.0. 74 cases were improved, 2 cases were markedly effective, but 3 cases were ineffective. The significant effective rate was 2.63%(2/76). The side effects include telangiectasia, skin atrophy, even arousing abnormal menstrual cycles and hair growth in several females. The comparability between the two groups was confirmed by the VSS scores before treatment(t=-1.114,P=0.267). Then, the difference of VSS scores became significant after treatment(t=-10.208, P<0.001), the same to apparent efficiency (χ2=12.450, P<0.001).
Conclusions Triamcinolone acetonide combined with hyaluronidase injection and shallow X-ray radiation therapy for multiple keloids has ideal curative effect and low incidence of adverse reactions, which is a prospected clinical method.